期刊
BIOSENSORS & BIOELECTRONICS
卷 90, 期 -, 页码 110-116出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2016.11.034
关键词
Paper-based sensor; Potentiometry; Enzymatic sensors; Glucose; Nafion
类别
资金
- European Union [PCIG09-GA-2011-293538]
- Ramon y Cajal Programme
- Spanish Ministerio de Economia y Competitividad [CTQ2013-46404-R]
- Generalitat de Catalunya [FI (2015 FI_B 00079)]
- Marti i Franques Programme from University Rovira i Virgili [2013PMF-PIPF-16]
A novel paper-based potentiometric sensor with an enhanced response for the detection of glucose in biological fluids is presented. The electrode consists on platinum sputtered on a filter paper and a Nafion membrane to immobilize the enzyme glucose oxidase. The response obtained is proportional to the logarithm of the concentration of glucose, with a sensitivity of -119 +/- 8 mV.decade(-1), a linear range that spans from 10(-4)M to 10(-2.5) M and a limit of detection of 10(-4.5) M of glucose. It is shown that Nafion increases the sensitivity of the technique while minimizing interferences. Validation with human serum samples shows an excellent agreement when compared to standard methods. This approach can become an interesting alternative for the development of simple and affordable devices for point of care and home-based diagnostics.
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