Engineered gadolinium-doped carbon dots for magnetic resonance imaging-guided radiotherapy of tumors

The effectiveness of radiotherapy can decrease due to inaccurate positioning of machinery and inherent radioresistance of tumors. To address this issue, we present a novel theranostic nanoplatform based on gadolinium-doped carbon dots (Gd-doped CDs) designed specifically for magnetic resonance imaging (MRI)-guided radiotherapy of tumors. The Gd-doped CDs (similar to 18 nm) with dispersibility in water and stable photoluminescence were synthesized via a one-step hydrothermal approach. After tail vein injection of the Gd-doped CDs, they exhibited a relatively long circulation time (similar to 6 h), enabled efficient passive tumor targeting. Gd-doped CDs accumulate in the kidney and could be cleared out of the body from bladder. Importantly, they exhibited favorable biocompatibility with excellent performance in longitudinal relaxivity rate (r(1)) of 6.45 mM(-1)S(-1) and radiosensitization enhancements. These results show that Gd-doped CDs are excellent T-1 contrast agents and radiosensitizers, possessing great promise for MRIguided radiotherapy of tumors. (C) 2016 Elsevier Ltd. All rights reserved.