期刊
ELIFE
卷 6, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.23190
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资金
- ANR [ANR-12-BSV5-0007-01, ANR-13-BSV2-0018, ANR-10-IDEX-0001-02, ANR11-LABX-0043, ANR-11-IDEX-0005-02, ANR-11-LABX-0071]
- Fondation pour la Recherche Medicale (FRM) [FRM DEQ20140329513]
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV2-0018] Funding Source: Agence Nationale de la Recherche (ANR)
T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4 T cell functions are affected by stiffness within the physiological Young's modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes. Yet, upon TCR/ CD3 stimulation, while cytokine production increases within a wide range of stiffness, from hundreds of Pa to hundreds of kPa, T cell metabolic properties and cell cycle progression are only increased by the highest stiffness tested (100 kPa). Finally, mechanical properties of adherent antigen-presenting cells modulate cytokine production by T cells. Together, these results reveal that T cells discriminate between the wide range of stiffness values found in the body and adapt their responses accordingly.
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