期刊
BIOTECHNOLOGY ADVANCES
卷 35, 期 2, 页码 178-216出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2016.12.005
关键词
Alzheimer's disease; Botanical
资金
- Govt. of West Bengal
- Department of Biotechnology, Govt. of India [BT/PR-11357/ INF/22/197/ 2014]
- North Eastern Hill University (NEHU) Shillong [793022]
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease associated with memory and cognition impairment ultimately leading to death. It is the commonest reason of dementia in elderly populations mostly affecting beyond the age of 65. The pathogenesis is indicated by accumulation of the amyloidbeta (A beta) plaques and neurofibrillary tangles (NFT) in brain tissues and hyperphosphorylation of tau protein in neurons. The main cause is considered to be the formation of reactive oxygen species (ROS) due to oxidative stress. The current treatment provides only symptomatic relief by offering temporary palliative therapy which declines the rate of cognitive impairment associated with AD. Inhibition of the enzyme acetylcholinesterase (AChE) is considered as one of the major therapeutic strategies offering only symptomatic relief and moderate
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