期刊
BIOMATERIALS
卷 121, 期 -, 页码 97-108出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.12.034
关键词
Lignin nanoparticles; Biocompatibility; Cellular uptake; Drug loading; Benzazulene; Antiproliferation effect
资金
- Finnish Cultural Foundation
- Fundacao para a Ciencia e a Tecnologia [SFRH/BD/110859/2015]
- Walter och Lisi Wahls Stiftelse for Naturvetenskaplig Forskning
- Academy of Finland [108376, 252215, 281300]
- University of Helsinki Research Funds
- Biocentrum Helsinki
- European Research Council under the European Union [310892]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/110859/2015] Funding Source: FCT
- Academy of Finland (AKA) [108376, 108376] Funding Source: Academy of Finland (AKA)
Currently, nanosystems have been developed and applied as promising vehicles for different biomedical applications. We have developed three lignin nanoparticles (LNPs): pure lignin nanoparticles (pLNPs), iron(III)-complexed lignin nanoparticles (Fe-LNPs), and Fe3O4-infused lignin nanoparticles (Fe3O4-LNPs) with round shape, narrow size distribution, reduced polydispersity and good stability at pH 7.4. The LNPs showed low cytotoxicity in all the tested cell lines and hemolytic rates below 12% after 12 h of incubation. Additionally, they induced hydrogen peroxide production in a small extent and time-dependent manner, and the interaction with the cells increased over time, exhibiting a dose-dependent cell uptake. Concerning the drug loading, pLNPs showed the capacity to efficiently load poorly water-soluble drugs and other cytotoxic agents, e.g. sorafenib and benzazulene (BZL), and improve their release profiles at pH 5.5 and 7.4 in a sustained manner. Furthermore, the BZL-pLNPs presented an enhanced antiproliferation effect in different cells compared to the pure BZL and showed a maximal inhibitory concentration ranging from 0.64 to 12.4 mu M after 24 h incubation. Overall, LNPs are promising candidates for drug delivery applications, and the superparamagnetic behavior of Fe3O4-LNPs makes them promising for cancer therapy and diagnosis, such as magnetic targeting and magnetic resonance imaging. (C) 2017 Elsevier Ltd. All rights reserved.
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