期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 8, 页码 6941-6949出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b00246
关键词
gadolinium oxide; gold nanocluster; near-infrared fluorescence; magnetic resonance imaging; X-ray computed tomography; photothermal/photodynamic therapy
资金
- Natural Science Foundation of China [21235010, 21475017, 21575020]
- Fundamental Research Funds for the Central Universities [N141008001, N140505003, 150502001, N152004005]
A protein-stabilized multifunctional theranostic nano-platform, gadolinium oxide-gold nanoclusters hybrid (Gd2O3-AuNCs), is constructed for multimodal imaging and drug delivery. The Gd2O3- AuNCs nanohybrid is developed by integrating Gd2O3 nanocrystals and gold nanoclusters into bovine serum albumin scaffold as a stabilizer. The nanohybrid exhibits favorable biocompatibility and is capable of enhancing the contrast in magnetic resonance and X-ray computed tomography imaging. Meanwhile, the integrated AuNCs component not only endows the nanohybrid to produce red fluorescence, but also sensitizes the generation of singlet oxygen (O-1(2)) upon near-infrared laser stimulation at 808 nm. Bovine serum albumin surrounding the nanoparticles makes Gd2O3-AuNCs a brilliant carrier for the delivery of indocyanine green (ICG). ICG loading endows the Gd2O3-AuNCs ICG nanocomposite with a near-infrared fluorescence imaging capability, and improves its photodynamic property and photothermal capability. Ultimately, further experiments have demonstrated that Gd2O3-AuNCs-ICG nanocomposite is a promising theranostic agent for image guided cancer therapy.
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