期刊
ACS NANO
卷 11, 期 3, 页码 3178-3188出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b00216
关键词
geometrical shape switch; acidity responsive; chimeric peptide; enhanced cellular internalization; photodynamic therapy
类别
资金
- National Natural Science Foundation of China [51603080, 21375043]
- Fundamental Research Funds for the Central Universities [2662015QD026]
Geometrical shape of nanoparticles plays an important role in cellular internalization. However, the applicability in tumor selective therapeutics is still scarcely reported. In this article, we designed a tumor extracellular acidity-responsive chimeric peptide with geometrical shape switch for enhanced tumor internalization and photodynamic therapy. This chimeric peptide could self-assemble into spherical nanoparticles at physiological condition. While at tumor extracellular acidic microenvironment, chimeric peptide underwent detachment of acidity-sensitive 2,3-dimethylmaleic anhydride groups. The subsequent recovery of ionic complementarity between chimeric peptides resulted in formation of rodlike nanoparticles. Both in vitro and in vivo studies demonstrated that this acidity-triggered geometrical shape switch endowed chimeric peptide with accelerated internalization in tumor cells, prolonged accumulation in tumor tissue, enhanced photodynamic therapy, and minimal side effects. Our results suggested that fusing microenvironment with geometrical shape switch should be a promising strategy for targeted drug delivery.
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