期刊
CURRENT DRUG DELIVERY
卷 14, 期 6, 页码 791-796出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567201814666161123152311
关键词
CNS disorders; glioblastoma; immunopathogenesis; ischemia; multiple sclerosis; PD-1/PD-Ls
资金
- Suzhou Key Medical Center [Szzx201501]
- National Natural Science Foundation of China [81571115, 81422013, 81471196]
- Scientific Department of Jiangsu Province [BL2014045]
- Suzhou Government [LCZX201301, SZS201413, SYS201332]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Background: Immune responses including Microglia and macrophage activation and peripheral immune cells infiltration have been founded in the central nervous system (CNS) in recent years. Thus, the traditional view of the adult brain as an immune-privileged organ has been changed. Methods: A systematic literature search was performed using Pubmed and Embase electronic data-bases without any limitations for a retrospective analysis. Results: The increase a number of studies indicated that the PD-1(programmed cell death-1)/PD-Ls signal pathway played an important role in regulating the immunopathogenesis of brain after injured. The relevant knowledges about PD-1/PD-Ls signal pathway, and potential effect with immune cells, cerebral ischemia, brain tumors and multiple sclerosis were reviewed in this paper. Conclusion: PD-1/PD-Ls played important roles in maintaining immunity balance and the development and prognosis of CNS diseases, but the specific mechanism was still not well understood.
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