期刊
CANCER SCIENCE
卷 108, 期 3, 页码 373-379出版社
WILEY
DOI: 10.1111/cas.13151
关键词
AR; lncRNA; prostate cancer; TLR3; TNFSF10
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Japan Society for the Promotion of Science
- National Institute of Biomedical Innovation, Japan
- Ministry of Health, Labor and Welfare, Japan
- Yasuda Memorial Foundation
- Princess Takamatsu Cancer Research Fund
- Grants-in-Aid for Scientific Research [15K15353, 15K15581, 16K18411] Funding Source: KAKEN
Although long non-coding RNAs (lncRNAs) have been associated with a variety of cancers, the interplay between lncRNAs and androgen receptor signaling in prostate cancer is still unclear. We identified an androgen-dependent lncRNA, POTEF-AS1, whose expression was regulated by androgen receptor in two androgen- dependent cells by using directional RNA sequencing analysis. POTEF-AS1 promoted cell growth, repressed genes related to the Toll-like receptor signaling and apoptosis pathways, and inhibited apoptosis in docetaxel-treated LNCaP cells. These findings suggest that POTEF-AS1 would play a key role in the progression of prostate cancer by repressing Toll-like receptor signaling.
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