期刊
INFECTION AND CHEMOTHERAPY
卷 49, 期 1, 页码 10-21出版社
KOREAN SOC ANTIMICROBIAL THERAPY
DOI: 10.3947/ic.2017.49.1.10
关键词
Sepsis; Multi-organ failure; Mitochondria; Immune cell; Metabolism
资金
- Korea University [K1032201, K1613721]
- National Institutes of Health [HL107585]
Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities.
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