期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 61, 期 -, 页码 117-126出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2016.11.013
关键词
Cerebral ischemia; Interleukin-1 receptor antagonist; Neuroprotection; Neurogenesis; Co-morbidity; Risk factors
资金
- Investing in Success grant from the University of Manchester (UK)
- MRC grant (UK) [G0802001/1]
- Spanish Ministry of Economy and Innovation [SAF2014-52225-R, SAF2015-68632-R]
- Biotechnology and Biological Sciences Research Council [BB/F011350/1] Funding Source: researchfish
- Medical Research Council [G0802001] Funding Source: researchfish
- BBSRC [BB/F011350/1] Funding Source: UKRI
- MRC [G0802001] Funding Source: UKRI
Neuroprotective strategies for ischemic stroke have failed to translate from bench to bedside, possibly due to the lack of consideration of key clinical co-morbidities. Stroke and co-morbidities are associated with raised levels of the pro-inflammatory cytokine interleukin-1 (IL-1). Inhibition of IL-1 by the administration of interleukin-1 receptor antagonist (IL-1Ra) has shown to be neuroprotective after experimental cerebral ischemia. Stroke can also trigger a robust neuroreparative response following injury, yet many of these new born neurons fail to survive or integrate into pre-existing circuits. Thus, we explore here effects of IL-1Ra on post-stroke neurogenesis in young and aged/co-morbid rats. Aged lean, aged Corpulent (a model of atherosclerosis, obesity and insulin resistance) and young Wistar male rats were exposed to transient cerebral ischemia, received subcutaneous IL-1Ra 3 and 6 h during reperfusion, and effects on stroke outcome and neurogenesis were analyzed. Our results show that administration of IL-1Ra improves stroke outcome in both young and aged/co-morbid rats. Furthermore, IL-1Ra not only increases stem cell proliferation, but also significantly enhances neuroblast migration and the number of newly born neurons after cerebral ischemia. Overall, our data demonstrate that systemic administration of IL-1Ra improves outcome and promotes neurogenesis after experimental stroke, further highlighting the therapeutic potential of this clinically approved drug. (C) 2016 The Authors. Published by Elsevier Inc.
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