期刊
BIOLOGICALS
卷 46, 期 -, 页码 64-67出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biologicals.2016.12.009
关键词
Metagenomics; Parvovirus; Bosavirus; Cell culture
资金
- NHLBI [RO1 HL105770]
- Blood Systems Research Institute
- Sigrid Juselius Foundation [WBS 4703764]
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20241864, BBS/E/D/20002174] Funding Source: researchfish
- BBSRC [BBS/E/D/20241864, BBS/E/D/20002174] Funding Source: UKRI
Using viral metagenomics we analyzed four bovine serum pools assembled from 715 calves in the United States. Two parvoviruses, bovine parvovirus 2 (BPV2) and a previously uncharacterized parvovirus designated as bosavirus (BosaV), were detected in 3 and 4 pools respectively and their complete coding sequences generated. Based on NS1 protein identity, bosavirus qualifies as a member of a new species in the copiparvovirus genus. Also detected were low number of reads matching ungulate tetraparvovirus 2, bovine hepacivirus, and several papillomaviruses. This study further characterizes the diversity of viruses in calf serum with the potential to infect fetuses and through fetal bovine serum contaminate cell cultures. (C) 2017 International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.
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