期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 8, 页码 6885-6893出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b15811
关键词
fluorescent magnetic microcapsules; Fe3O4 nanoparticles; wide-field illumination laser microscope; rat mesentery; blood flow; drug delivery
资金
- Government of the Russian Federation [14.Z50.31.0004]
- Russian Science Foundation [16-15-10252]
- Russian Science Foundation [16-15-10252] Funding Source: Russian Science Foundation
Remote navigation and targeted delivery of biologically active compounds is one of the current challenges in the development of drug delivery systems. Modern methods of micro- and nano- fabrication give us new opportunities to produce particles and capsules bearing cargo to deploy and possess magnetic properties to be externally navigated. In this work we explore multilayer composite magnetic microcapsules as targeted delivery systems in vitro and in vivo studies under natural conditions of living organism. Herein, we demonstrate magnetic addressing of fluorescent composite micro capsules with embedded magnetite nanoparticles in blood flow environment. First, the visualization and capture of the capsules at the defined blood flow by the magnetic field are shown in vitro in an artificial glass capillary employing a wide-field fluorescence microscope. Afterward, the capsules are visualized and successfully trapped in vivo into externally exposed rat mesentery microvessels. Histological analysis shows that capsules infiltrate small mesenteric vessels whereas large vessels preserve the blood microcirculation. The effect of the magnetic field on capsule preferential localization in bifurcation areas of vasculature, including capsule retention at the site once external magnet is switched off is discussed. The research outcome demonstrates that microcapsules can be effectively addressed in a blood flow, which makes them a promising delivery system with remote navigation by the magnetic field.
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