期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 137, 期 -, 页码 179-185出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2016.12.002
关键词
Insecticides; Cytotoxicity; Human cells; Insect cells; Cell-based systems
资金
- Shanghai Foundation of Science and Technology [15431906800]
The cytotoxic potential of 13 commonly used agricultural insecticides was examined using cell-based systems with three human HepG2, Hek293, HeLa cells and three insect Tn5B1-4, Sf-21, and Drosophila S2 cells. Data showed that (1) an enhancement of some insecticides (e.g. pyrethroids) on cells proliferation; (2) an inhibition of some insecticides on cells viability; (3) various levels of susceptibility of different cells to the same insecticide; and (4) the cell type dependent sensitivity to different insecticides. The degree of cytotoxicity of insecticides on human cells was significantly lower than that on insect cells (P < 0.05). Methomyl, even 20 mu g/ml, showed little cytotoxicity at 24 h exposure whereas emamectin benzoate possessed the strongest cytotoxic potential in a dose dependent fashion. The results revealed comparable cytotoxic property of agricultural insecticides against intact cells.
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