期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 769, 期 -, 页码 333-341出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2015.11.038
关键词
Hesperetin; Ventilator-induced ALI; PPAR-gamma; NF-kappa B pathway; Inflammation
Hesperetin, a major bioflavonoid in sweet oranges and lemons, has been reported to have anti-inflammatory properties. However, the effect of hesperetin on ventilator-induced acute lung injury has not been studied. In present study, we investigated the protective effect of hesperetin on ventilator-induced acute lung injury in rats. Rats were orally administered hesperetin (10, 20, or 40 mg/kg) two hour before acute lung injury was induced by mechanical ventilation. Rats were then randomly divided into six groups: the lung protective ventilation group (n =20, LV group), injurious ventilation group (n=20, HV group), vehicle-treated injurious ventilation group (n=20, LV+vehicle group), hesperetin (10 mg/kg)treated acute lung injury group (n=20, HV+Hsp (10 mg)), hesperetin (20 mg/kg)-treated acute lung injury group (n=20, HV+Hsp (20 mg)), and hesperetin (40 mg/kg)-treated acute lung injury group (n=20, HV+Hsp (40 mg)). The lung tissues and bronchoalveolar lavage fluid were isolated for subsequent measurements. Treatment with hesperetin dramatically improved the histology of lung tissue, and reduced the wet/dry ratio, myeloperoxidase activity, protein concentration, and production of tumor necrosis factor (TNE)-alpha, interleukin (IL)-6, IL-1 beta, and MIP-2 in the bronchoalveolar lavage fluid of rats with ventilator-induced acute lung injury. Additionally, our study indicated that this protective effect of hesperetin results from its ability to increase the expression of peroxisome proliferator-activated receptor (PPAR)-7 and inhibit the activation of the nuclear factor (NF)-kappa B pathway. These results suggest that hesperetin may be a potential novel therapeutic candidate for protection against ventilator-induced acute lung injury. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据