期刊
DEVELOPMENT
卷 144, 期 5, 页码 737-754出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.145441
关键词
Kruppel-like factors; Stem cells; Mammalian development; Cellular regeneration; Human disease
资金
- National Institutes of Health
- American Heart Association
- Dialysis Clinic, Inc
Kruppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in many species. Recent studies have shown that KLFs play a fundamental role in regulating diverse biological processes such as cell proliferation, differentiation, development and regeneration. Of note, several KLFs are also crucial for maintaining pluripotency and, hence, have been linked to reprogramming and regenerative medicine approaches. Here, we review the crucial functions of KLFs in mammalian embryogenesis, stem cell biology and regeneration, as revealed by studies of animal models. We also highlight how KLFs have been implicated in human diseases and outline potential avenues for future research.
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