期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 25, 期 2, 页码 795-804出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2016.11.059
关键词
Freshwater fungi; alpha-Pyrones; Tetrahydroxanthones; Cyclodepsipeptides; Bacterial peptidyl-tRNA hydrolase
资金
- University of North Carolina at Greensboro
- National Science Foundation-United States [CHE-0234489]
Eighteen (1-18) and seven (1, 4, 6-8,17 and 18) compounds were isolated from organic extracts of axenic cultures of two freshwater fungi Clohesyomyces sp. and Clohesyomyces aquaticus (Dothideomycetes, Ascomycota), respectively. Compounds 1-12 belong to the cc-pyrone class of natural products, compounds 13 and 14 were tetrahydroxanthones, compounds 15 and 16 were hexahydroxanthones, while compounds 17 and 18 were cyclodepsipeptides. The structures were elucidated using a set of spectroscopic and spectrometric techniques. The absolute configurations of compounds 2, 3, 6, and 7 were assigned via a modified Mosher's ester method using H-1 NMR data. The relative configurations of compounds 14-16 were determined through NOE data. Compounds 1, 2, 6, 8, 13, 14, and 15 were found to inhibit the essential enzyme bacterial peptidyl-tRNA hydrolase (Pth1), with (13; secalonic acid A) being the most potent. Compounds 1 and 4-18 were also evaluated for antimicrobial activity against an array of bacteria and fungi but were found to be inactive. (C) 2016 Elsevier Ltd. All rights reserved.
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