期刊
ACS NANO
卷 11, 期 1, 页码 797-805出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b07196
关键词
molecular assembly; supramolecular nanofibers; MRI; CEST; anticancer drugs
类别
资金
- National Science Foundation [DMR 1255281]
- National Institutes of Health [NIH/R21EB015609, NIH/R21CA191740, NIH/R01EB019934, NIH/R03EB021573]
- Key Medicine Discipline Construction of Guangzhou Municipality [2013-21]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1255281] Funding Source: National Science Foundation
Gadolinium (Gd)-based compounds and materials are the most commonly used magnetic resonance imaging (MRI) contrast agents in the clinic; however, safety concerns associated with their toxicities in the free ionic form have promoted the development of new generations of metal-free contrast agents. Here we report a supramolecular strategy to convert an FDA-approved anticancer drug, Pemetrexed (Pem), to a molecular hydrogelator with inherent chemical exchange saturation transfer (CEST) MRI signals. The rationally designed drug peptide conjugate can spontaneously associate into filamentous assemblies under physiological conditions and consequently form theranostic supra-molecular hydrogels for injectable delivery. We demonstrated that the local delivery and distribution of Pem peptide nanofiber hydrogels can be directly assessed using CEST MRI in a mouse glioma model. Our work lays out the foundation for the development of drug-constructed theranostic supramolecular materials with an inherent CEST MRI signal that enables noninvasive monitoring of their in vivo distribution and drug release.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据