期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 27, 期 5, 页码 1225-1232出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2017.01.063
关键词
Lachnum exopolysaccharide; Structural features; Antioxidant; Moisture absorption; Moisture retention
资金
- National Natural Science Foundation of China [31470146]
A water-soluble exopolysaccharide, designated as LEP-2a, was isolated from Lachnum YM262 and purified by DEAE-Cellulose 52 and Sepharose CL-6B chromatographic columns. LEP-2a was a homogeneous polysaccharide, with a molecular weight of 1.52 x 10(5) Da. It was composed of mannose and galactose in a molar ratio of 20.6:1.0. Its structural features were investigated and elucidated by methylation analysis, periodate oxidation and Smith degradation, FT-IR and NMR spectroscopy. Based on obtained data, the backbone of LEP-2a consisted of 1,2-linked-alpha-D-mannose, 1,3-linked-alpha-D-mannose, 1,2,6-linked-alpha-D-mannose and 1,3-linked-beta-D-galactose and the side chains were attached to the backbone at 0-6 position of 1,2,6-linked-alpha-D-mannose. In vitro antioxidant activity assay proved that LEP-2a possessed significant scavenging activities on superoxide, hydroxyl and DPPH radical. Furthermore, LEP-2a had strong in vitro moisture-absorption and -retention capacities as compared to chitosan and glycerol. These results suggested that LEP-2a might have a good potential to be applied as a multifunctional cosmetic additive in cosmetics. (C) 2017 Elsevier Ltd. All rights reserved.
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