期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 11, 页码 2889-2892出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201610649
关键词
graphene; imaging agents; nanoparticles; positron emission tomography; radiolabeling
资金
- University of Wisconsin-Madison
- National Institutes of Health [NIBIB/NCI 1R01CA169365, 1R01EB021336, P30CA014520, T32CA009206, T32GM008505]
- American Cancer Society [125246-RSG-13-099-01-CCE]
- Grainger Foundation (Wisconsin Distinguished Graduate Fellowship)
Macrocyclic chelators have been widely employed in the realm of nanoparticle-based positron emission tomography (PET) imaging, whereas its accuracy remains questionable. Here, we found that Cu-64 can be intrinsically labeled onto nanographene based on interactions between Cu and the p electrons of graphene without the need of chelator conjugation, providing a promising alternative radiolabeling approach that maintains the native in vivo pharmacokinetics of the nanoparticles. Due to abundant p bonds, reduced graphene oxide (RGO) exhibited significantly higher labeling efficiency in comparison with graphene oxide (GO) and exhibited excellent radiostability in vivo. More importantly, nonspecific attachment of 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) on nanographene was observed, which revealed that chelator-mediated nanoparticle-based PET imaging has its inherent drawbacks and can possibly lead to erroneous imaging results in vivo.
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