期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 11, 页码 2923-2926出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201611288
关键词
block co-polymers; FRET; high-density lipoproteins; microfluidics; nanoemulsions
资金
- National Institute of Health [R01 HL118440, R01 HL125703, R01 CA155432, R01 EB009638]
- Harold S. Geneen Charitable Trust Award
- NWO VIDI
- Norwegian Research Council [230788/F20]
Understanding the formation process of nanoparticles is of the utmost importance to improve their design and production. This especially holds true for self-assembled nanoparticles whose formation processes have been largely overlooked. Herein, we present a new technology that integrates a microfluidic-based nanoparticle synthesis method and Forster resonance energy transfer (FRET) microscopy imaging to visualize nanoparticle self-assembly in real time. Applied to different nanoparticle systems, for example, nanoemulsions, drug-loaded block-copolymer micelles, and nanocrystal-core reconstituted high-density lipoproteins, we have shown the approach's unique ability to investigate key parameters affecting nanoparticle formation.
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