期刊
DEVELOPMENT
卷 144, 期 2, 页码 187-200出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.122804
关键词
Cell migration; Planar cell polarity; Planar polarity
资金
- National Institutes of Health (NIH)
- UW Developmental Biology Training Grant from the NIH
The planar cell polarity (PCP) pathway is best known for its role in polarizing epithelial cells within the plane of a tissue but it also plays a role in a range of cell migration events during development. The mechanism by which the PCP pathway polarizes stationary epithelial cells is well characterized, but how PCP signaling functions to regulate more dynamic cell behaviors during directed cell migration is much less understood. Here, we review recent discoveries regarding the localization of PCP proteins in migrating cells and their impact on the cell biology of collective and individual cell migratory behaviors.
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