期刊
CURRENT MEDICAL IMAGING REVIEWS
卷 13, 期 1, 页码 50-57出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573405612666160607094334
关键词
Cerenkov luminescence imaging; Endoscopy; Gastrointestinal disease; Molecular imaging; Optical imaging
资金
- National Natural Science Foundation of China [81227901, 81230033, 81571725]
- Natural Science Basic Research Plan in Shaanxi Province of China [2015JQ6249, 2015JZ019]
- Fundamental Research Funds for Central Universities [NSIZ021402, NSIY061406]
The Cerenkov luminescence imaging (CLI) has built a bridge between the nuclear and optical imaging, and opened a new direction of optical imaging in clinic translation. However, the wide applications of CLI are limited by the weak intensity and poor penetration capacity. By coupling highly sensitive charged coupled device camera with optical fiber bundle based endoscope, Cerenkov luminescence endoscopy (CLE) has recently been developed to overcome these limitations. Using the CLE, diseases deep buried in the body, such as the gastrointestinal (GI) tract cancer, can be identified by radiotracer, which can hardly be detected by CLI from the surface of the body. Here, we review recent progress on CLI and CLE, including the principle, imaging instrument, as well as applications. In addition, the intensity enhanced strategies for Cerenkov luminescence are presented, which may provide an ideal solution to the obstacle of CLE in the translation studies. In the end, we present possible future directions of the CLE technology.
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