期刊
BIOTECHNOLOGY JOURNAL
卷 12, 期 3, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201600099
关键词
Agricultural productivity; Human health; Microbiome engineering; Microbiota
资金
- Synthetic Biology Initiative of the National University of Singapore [DPRT/943/09/14]
- National Medical Research Council of Singapore (NMRC) [CBRG/0011a/2012]
- Agency for Science, Technology and Research of Singapore (A*STAR) [SERC 112 177 0040]
- Ministry of Defence of Singapore (MINDEF) [RE2016-074]
- Singapore-MIT Alliance for Research and Technology Center (SMART) [RL2015-072]
- U.S. Air Force (AOARD) [FA2386-14-1-4060]
- Defense Threat Reduction Agency (DTRA) [HDTRA1-13-1-0037]
Microbiomes exist in all ecosystems and are composed of diverse microbial communities. Perturbation to microbiomes brings about undesirable phenotypes in the hosts, resulting in diseases and disorders, and disturbs the balance of the associated ecosystems. Engineering of microbiomes can be used to modify structures of the microbiota and restore ecological balance. Consequently, microbiome engineering has been employed for improving human health and agricultural productivity. The importance and current applications of microbiome engineering, particularly in humans, animals, plants and soil is reviewed. Furthermore, we explore the challenges in engineering microbiome and the future of this field, thus providing perspectives and outlook of microbiome engineering.
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