Dynamic thiol/disulfide homeostasis in children with attention deficit hyperactivity disorder and its relation with disease subtypes

Background: The aim of this study was to evaluate a novel oxidative stress marker (thiol/disulfide homeostasis) in attention deficit hyperactivity disorder (ADBD) children for the first time in literature. Methods: Ninety children with ADHD diagnosed according to DSM-V and as control group, 65 healthy children were included to the study. Native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol were compared between the groups. Results: Total and native thiol levels were significantly higher whereas the disulfide/native thiol ratios were significantly lower in children with ADBD. ADHD combined type appeared to have higher disulfide, disulfide/native thiol and disulfide/total thiol ratios compared to other subtypes. Disulfide levels of the males with ADBD were significantly higher than those of the females with AMID. Conclusion: This study suggests that thiol/disulfide homeostasis is abnormal in children with ADHD. It may be used as a novel OS marker in ADBD children because it is easy, practical, fully automated and relatively inexpensive. (C) 2016 Elsevier Inc. All rights reserved.