期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 27, 期 3, 页码 361-369出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.12.025
关键词
DNA-encoded library; Drug discovery; High throughput screening; Combinatorial chemistry; Dynamic combinatorial library
资金
- General Research Fund of the University Grants Committee of Hong Kong [17321916]
- University of Hong Kong start-up fund
- Seed Fund Program for Basic Research from the University of Hong Kong
DNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for ligand discovery in chemical biology research and in drug discovery. Encoding and selection methods are two of the most important technological aspects of DEL that can dictate the performance and utilities of DELs. In this digest, we have summarized recent advances on the encoding and selection strategies of DEL and also discussed the latest developments on DNA-encoded dynamic library, a new frontier in DEL research. (C) 2016 Elsevier Ltd. All rights reserved.
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