期刊
CELL
卷 168, 期 6, 页码 1126-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2017.02.001
关键词
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资金
- NSF [DEB-1457695, NSFOCE-BSF-1635070]
- US DOE [DE-SC0012627]
- Human Frontier Science Program
- National Institute of General Medical Sciences of the National Institutes of Health [T32GM100842]
- U.S. Department of Energy (DOE) [DE-SC0012627] Funding Source: U.S. Department of Energy (DOE)
Phosphate is essential for all living systems, serving as a building block of genetic and metabolic machinery. However, it is unclear how phosphate could have assumed these central roles on primordial Earth, given its poor geochemical accessibility. We used systems biology approaches to explore the alternative hypothesis that a protometabolism could have emerged prior to the incorporation of phosphate. Surprisingly, weidentified a cryptic phosphate-independent core metabolism producible from simple prebiotic compounds. This network is predicted to support the biosynthesis of a broad category of key biomolecules. Its enrichment for enzymes utilizing iron-sulfur clusters, and the fact that thermodynamic bottlenecks are more readily overcome by thioester rather than phosphate couplings, suggest that this network may constitute a metabolic fossil'' of an early phosphate-free nonenzymatic biochemistry. Our results corroborate and expand previous proposals that a putative thioester-based metabolism could have predated the incorporation of phosphate and an RNA-based genetic system.
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