期刊
CIRCULATION
卷 135, 期 11, 页码 1075-1092出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCULATIONAHA.116.024534
关键词
heart diseases; ischemia
资金
- National Heart, Lung, and Blood Institutes [N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164, RO1-, HL-073412-01, U01-64829, U01-HL649141, U01-HL649241, UL1-TR001427]
- Gustavus and Louis Pfeiffer Research Foundation, Danville, NJ
- Women's Guild of Cedars-Sinai Medical Center, Los Angeles, CA
- Ladies Hospital Aid Society of Western Pennsylvania, Pittsburgh, PA
- QMED, Inc, Laurence Harbor, NJ
- Edythe L. Broad Endowment
- Barbra Streisand Women's Cardiovascular Research and Education Program
- Linda Joy Pollin Women's Heart Health Program
- Constance Austin Fellowship Endowment, Cedars-Sinai Medical Center, Los Angeles
- Erika Glazer Women's Heart Health Project, Cedars-Sinai Medical Center, Los Angeles, California
- American College of Cardiology
The Cardiovascular Disease in Women Committee of the American College of Cardiology, in conjunction with interested parties (from the National Heart, Lung, and Blood Institute, American Heart Association, and European Society of Cardiology), convened a working group to develop a consensus on the syndrome of myocardial ischemia with no obstructive coronary arteries. In general, these patients have elevated risk for a cardiovascular event (including acute coronary syndrome, heart failure hospitalization, stroke, and repeat cardiovascular procedures) compared with reference subjects and appear to be at higher risk for development of heart failure with preserved ejection fraction. A subgroup of these patients also has coronary microvascular dysfunction and evidence of inflammation. This document provides a summary of findings and recommendations for the development of an integrated approach for identifying and managing patients with ischemia with no obstructive coronary arteries and outlines knowledge gaps in the area. Working group members critically reviewed available literature and current practices for risk assessment and state-of-the-science techniques in multiple areas, with a focus on next steps needed to develop evidence-based therapies. This report presents highlights of this working group review and a summary of suggested research directions to advance this field in the next decade.
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