The correlation between lymphocyte/monocyte ratio and coronary collateral circulation in stable coronary artery disease patients

Aim: Coronary collateral circulation (CCC) has an important impact on cardiovascular prognosis and well-developed CCC is associated with better clinical outcomes. We investigated whether lymphocyte/monocyte ratio (LMR) has an association with CCC in patients with stable coronary artery disease (SCAD). Methods: The study population consisted of 245 patients with SCAD. Patients were classified into a poor CCC group (Rentrop grades 0/1, n = 87), or good CCC group (Rentrop grades 2/3, n = 158). Results: LMR values were significantly higher in patients with good CCC than in those with poor CCC (4.41 +/- 1.58 vs 2.76 +/- 1.10; p < 0.001). In receiver operating characteristic analysis, optimal cutoff of LMR for predicting well-developed CCC was 3.38. In multivariate analysis, LMR > 3.38 (OR 4.637; p = 0.004), high sensitivity C-reactive protein (OR 0.810; p < 0.001), dyslipidemia (OR 2.485; p = 0.039), and presence of chronic total occlusion (OR 16.836; p < 0.001) were independent predictors of well-developed CCC. Conclusion: Increased LMR predicts well-developed CCC in SCAD patients.