期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 97, 期 -, 页码 338-349出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2015.05.017
关键词
Thermosensitive hydrogels; In situ gelation; Drug delivery; Tissue engineering; Cell sheet engineering; Lower critical solution temperature; Sol-gel transition
Thermally responsive hydrogels modulate their gelation behavior upon temperature change. Aqueous solutions solidify into hydrogels when a critical temperature is reached. In biomedical applications, the change from ambient temperature to physiological temperature can be employed. Their potential as in situ forming biomaterials has rendered these hydrogels very attractive. Advances in drug delivery, tissue engineering and cell sheet engineering have been made in recent years with the use of thermoresponsive hydrogels. The scope of this article is to review the literature on thermosensitive hydrogels published over the past seven years. The article concentrates on natural polymers as well as synthetic polymers, including systems based on N-isopropylacrylamide (NIPAAm), poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO), poly( ethylene glycol) (PEG)-biodegradable polyester copolymers, poly( organophosphazenes) and 2-(dimethylamino) ethyl methacrylate (DMAEMA). (C) 2015 Elsevier B.V. All rights reserved.
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