期刊
BIOSENSORS & BIOELECTRONICS
卷 89, 期 -, 页码 1059-1067出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2016.09.109
关键词
Capacitive biosensor; AC electrokinetics (ACEK); Point-of-care (POC) diagnostics; Small molecule detection
类别
资金
- University of Tennessee (UT) Center for Wildlife Health
- Ministry of Science, Research and Technology (MSRT) of Iran
- UT Initiative for Point Detection and Nanobiosensing
A rapid, highly sensitive, specific and low-cost capacitive affinity biosensor is presented here for label-free and single step detection of Bisphenol A (BPA). The sensor design allows rapid prototyping at low-cost using printed circuit board material by benchtop equipment. High sensitivity detection is achieved through the use of a BPA-specific aptamer as probe molecule and large electrodes to enhance AC-electroelectrothermal effect for long-range transport of BPA molecules toward electrode surface. Capacitive sensing technique is used to determine the bounded BPA level by measuring the sample/electrode interfacial capacitance of the sensor. The developed biosensor can detect BPA level in 20 s and exhibits a large linear range from 1 fM to 10 pM, with a limit of detection (LOD) of 152.93 aM. This biosensor was applied to test BPA in canned food samples and could successfully recover the levels of spiked BPA. This sensor technology is demonstrated to be highly promising and reliable for rapid, sensitive and on-site monitoring of BPA in food samples.
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