期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 92, 期 -, 页码 28-31出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2015.02.018
关键词
Mesoporous silica; Supercritical carbon dioxide; Hydrophobic molecules; Amorphous; Bioavailability; Dissolution
资金
- National Natural Science Foundation of China [81173002]
- National Science and Technology Pillar Program [2012BAI35B02]
The aim of this study was to load amorphous hydrophobic drug into ordered mesoporous silica (SBA-15) by supercritical carbon dioxide technology in order to improve the dissolution and bioavailability of the drug. Asarone was selected as a model drug due to its lipophilic character and poor bioavailability. In vitro dissolution and in vivo bioavailability of the obtained Asarone-SBA-15 were significantly improved as compared to the micronized crystalline drug. This study offers an effective, safe, and environmentally benign means of solving the problems relating to the solubility and bioavailability of hydrophobic molecules. (C) 2015 Elsevier B.V. All rights reserved.
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