期刊
BIOSENSORS & BIOELECTRONICS
卷 89, 期 -, 页码 846-852出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2016.09.108
关键词
Co3O4; Crumpled graphene; Peroxidase mimetic; Colorimetric; Ascorbic acid detection
类别
资金
- National Natural Science Foundation of China [51602298, 51572249]
- Qingdao City Programs for Science and Technology Plan Projects [15-9-1-82-jch]
- Natural Science Foundation of Shandong Province [ZR2014EMM021]
- Natural High Technology Research and Development Program of China [2013A2041106]
- Fundamental Research Funds for the Central University [841562011]
The well-dispersed Co3O4 nanoparticles-decorated crumpled graphene microsphere (CGM) was successfully prepared by aerosol-assisted frying self-assembly and annealing process. It is found that the obtained Co3O4/CGM nanohybrid possessed enhanced intrinsic peroxidase-like activity and could catalytically oxidize 3,3',5,5'-tetramethylbenzidine by H2O2 to produce a typical blue product. But the presence of ascorbic acid could induce the reduction of oxTMB to TMB, resulting in a significant blue color fading. Therefore, a simple, sensitive and selective colorimetric method to detect ascorbic acid was established with a good linear relationship (30-140 mu M) and a low detection limit of 0.19 mu M. Meanwhile, the selectivity, stability and repeatability were acceptable. It is also a facile route to fabricate nanoparticles/CGM as high-performance enzyme mimetic for colorimetric biosensing.
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