期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 94, 期 -, 页码 322-332出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2015.06.002
关键词
Curcumin; Eudragit (R) E PO; Solid dispersion; Water solubility; Stability; Transdermal administration
资金
- Kyung-Nong Company
- International Research & Development Program of the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology (MEST) of Korea [2012K1A3A1A20031356]
- Korea University grant
- Institute of Biomedical Science & Food Safety, Korea University Food Safety Hall
Using a simple solution mixing method, curcumin was dispersed in the matrix of Eudragit (R) E PO polymer. Water solubility of curcumin in curcumin-Eudragit (R) E PO solid dispersion (Cur@EPO) was greatly increased. Based on the results of several tests, curcumin was demonstrated to exist in the polymer matrix in amorphous state. The interaction between curcumin and the polymer was investigated through Fourier transform infrared spectroscopy and H-1 NMR which implied that OH group of curcumin and carbonyl group of the polymer involved in the H bonding formation. Cur@EPO also provided protection function for curcumin as verified by the pH challenge and UV irradiation test. The pH value influenced curcumin release profile in which sustained release pattern was revealed. Additionally, in vitro transdermal test was conducted to assess the potential of Cur@EPO as a vehicle to deliver curcumin through this alternative administration route. (C) 2015 Elsevier B.V. All rights reserved.
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