期刊
CELL CHEMICAL BIOLOGY
卷 24, 期 3, 页码 252-280出版社
CELL PRESS
DOI: 10.1016/j.chembiol.2017.02.010
关键词
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资金
- National Basic Research Program of China [2015CB964800, 2014CB964900]
- National Natural Science Foundation of China [31571514]
- Hundred Talents Program of Chinese Academy of Sciences
- State Key Laboratory of Stem Cell and Reproductive Biology
- NIH [NS033642]
The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in embryonic patterning and development. Since its discovery, it has become increasingly clear that the HH pathway also plays important roles in a multitude of cancers. Therefore, HH signaling has emerged as a therapeutic target of interest for cancer therapy. In this review, we provide a brief overview of HH signaling and the key molecular players involved and offer an up-to-date summary of our current knowledge of endogenous and exogenous small molecules that modulate HH signaling. We discuss experiences and lessons learned from the decades-long efforts toward the development of cancer therapies targeting the HH pathway. Challenges to develop next-generation cancer therapies are highlighted.
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