期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 359, 期 6, 页码 913-918出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201700146
关键词
amine-thiourea catalysts; asymmetric catalysis; electron-deficient compounds; epoxidation; glycidic esters; organocatalysis
资金
- MIUR
- POR Regione Campania FESR O.O. 2.1 (FarmaBioNet)
- Danish National Research Foundation [DNRF-93]
- University of Salerno
A novel class of synthetically important glycidic esters has been obtained via an asymmetric epoxidation of trans-alpha-cyano-alpha, beta-unsaturated esters catalysed by a multifunctional Cinchona alkaloidderived thiourea/tert-butyl hydroperoxide (TBHP) system. The glycidic esters, isolated in excellent yield with complete trans-diastereocontrol and high enantioselectivity, proved to be versatile building blocks to access challenging small targets bearing a quaternary stereocenter.
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