4.8 Article

Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle-Like Functions

期刊

ADVANCED MATERIALS
卷 29, 期 11, 页码 -

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201605375

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资金

  1. Academy of Finland [252215, 281300, 277423]
  2. University of Helsinki
  3. Biocentrum Helsinki
  4. European Research Council under the European Union [310892]
  5. Jane and Aatos Erkko Foundation [4704010]
  6. TEKES [40395/13]
  7. Academy of Finland (AKA) [277423, 277423] Funding Source: Academy of Finland (AKA)

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A new biomimetic nanoreactor design is presented based on cancer cell membrane material in combination with porous silicon nanoparticles. This cellular nanoreactor features a biocompartment enclosed by a cell membrane and readily integrated with cells and supplementing the cellular functions under oxidative stress. The study demonstrates the impact of the nanoreactors on improving cellular functions with a potential to serve as artificial organelles.

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