期刊
CELL METABOLISM
卷 25, 期 2, 页码 386-399出版社
CELL PRESS
DOI: 10.1016/j.cmet.2017.01.002
关键词
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资金
- American Diabetes Association [1-16-PDF-108]
- Joslin Pilot and Feasibility Program [P30DK03683629]
- NIH [R01 GM095746, R01 DK083694]
- HHMI
While high-caloric diet impairs insulin response to cause hyperglycemia, whether and how counter-regulatory hormones are modulated by high-caloric diet is largely unknown. We find that enhanced response of Drosophila adipokinetic hormone (AKH, the glucagon homolog) in the fat body is essential for hyperglycemia associated with a chronic high-sugar diet. We show that the activin type I receptor Baboon (Babo) autonomously increases AKH signaling without affecting insulin signaling in the fat body via, at least, increase of Akh receptor (AkhR) expression. Further, we demonstrate that Activin-beta (Act beta), an activin ligand predominantly produced in the enteroendocrine cells (EEs) of the midgut, is upregulated by chronic high-sugar diet and signals through Babo to promote AKH action in the fat body, leading to hyperglycemia. Importantly, activin signaling in mouse primary hepatocytes also increases glucagon response and glucagon-inducedglucose production, indicating a conserved role for activin in enhancing AKH/glucagon signaling and glycemic control.
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