期刊
BIOMATERIALS SCIENCE
卷 5, 期 1, 页码 38-40出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6bm00683c
关键词
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资金
- National Cancer Institute Center of Cancer Nanotechnology Excellence at MIT-Harvard [U54-CA151884]
- National Heart, Lung, and Blood Institute, the National Institutes of Health (NIH), as a Program of Excellence in Nanotechnology (PEN) Award [HHSN268201000045C]
- NIH [R01-EB000244-27, 5-R01-CA132091-04, R01-DE016516-03]
- Department of Defense Congressionally Directed Medical Research Program (DOD/CDMRP) postdoctoral fellowships [W81XWH-13-1-0215]
- Bayer Hemophilia Awards Program for the Early Career Investigator Award
- National PKU Alliance for Research Awards
- AAPS Foundation for New Investigator Grant
- National Institute of General Medical Sciences for the Maximizing Investigators' Research Award [1R35GM119679]
- start-up fund from the College of Pharmacy at The Ohio State University
Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.
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