期刊
BIOMATERIALS SCIENCE
卷 5, 期 12, 页码 2369-2380出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7bm00730b
关键词
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资金
- National Key Research and Development Program of China [2017YFA0103802]
- National Natural Science Foundation of China [51503129]
- Thousand Talents Plan for Young Professionals, Guangdong Innovative and Entrepreneurial Research Team Program [2013S086]
- Guangdong Natural Science Foundation [2014A030312018]
- Science and Technology Planning Project of Guangdong Province [2016A010103015]
- Science and Technology Program of Guangzhou [201707010094]
Peptide amphiphiles (PAs), functionalized with alkyl chains, are capable of self-assembling into various nanostructures. Recently, PAs have been considered as ideal drug carriers due to their good biocompatibility, specific biological functions, and hypotoxicity to normal cells and tissues. Meanwhile, the nanocarriers formed by PAs are able to achieve controlled drug release and enhanced cell uptake in response to the stimulus of the physiological environment or specific biological factors in the location of the lesion. However, the underlying detailed drug delivery mechanism, especially from the aspect of primary and secondary structures of PAs, has not been systematically summarized or discussed. Focusing on the relationship between the primary and secondary structures of PAs and stimuli-responsive drug delivery applications, this review highlights the recent advances, challenges, and opportunities of PA-based functional drug nanocarriers, and their potential pharmaceutical applications are discussed.
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