期刊
JOURNAL OF IMMUNOTHERAPY
卷 40, 期 2, 页码 77-82出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CJI.0000000000000154
关键词
Vogt-Koyanagi-Harada syndrome; uveitis; melanoma; toxicity; anti-PD-1; immunotherapy
Vogt-Koyanagi-Harada (VKH) syndrome is a rare condition implicating systemic immune reaction against melano-cytes. The pathophysiology is unclear. A genetic predisposition has been suggested as HLA-DR4/DRB1*04 is more common among VKH patients. Drug induced VKH syndrome has been reported in advanced melanoma patients receiving immunotherapy, including ipilimumab and adoptive cell transfer of Tumor-Infiltrating Lymphocyte associated with IL-2. To date, no case of anti PD-1-induced VKH syndrome has been described. We report here the case of a HLA-DR4/DRB1*04 patient successfully treated with anti PD-1 for advanced melanoma who developed a systemic immune reaction against melanocytes for whom we discuss a VKH-like syndrome diagnosis in a potentially genetically predisposed patient.
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