期刊
BIOMATERIALS SCIENCE
卷 5, 期 8, 页码 1526-1530出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7bm00304h
关键词
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资金
- University of Notre Dame through the Advancing our Vision initiative
- Harper Cancer Institute-American Cancer Society Institutional Research Grant [IRG-14-195-01]
Supramolecular chemistry enables the creation of a diversity of nanostructures and materials. Many of these have been explored for applications as biomaterials and therapeutics. Among them, self-assembling peptides have been broadly applied. The structural diversity afforded from the library of amino acid building blocks has enabled control of emergent properties across length-scales. Here, we report on a family of amphiphilic tripeptides with sequence-controlled nanostructure. By altering one amino acid in these peptides, we can produce a diversity of nanostructures with different aspect-ratio and geometry. Peptides that produce high aspect-ratio structures can physically entangle to form hydrogels, which support cell viability in culture. Importantly, in comparison to many other short self-assembling peptide biomaterials, those reported here form filamentous nanostructures in the absence of typical secondary structures (i.e., beta-sheet). Thus, we have illustrated a facile way to obtain versatile biomaterials with different nanostructural morphology from short and defined peptide sequences.
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