期刊
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
卷 312, 期 2, 页码 F266-F275出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajprenal.00473.2016
关键词
premature cell senescence; sirtuin 1; nitric oxide; endothelial glycocalyx; lysosomal dysfunction
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [DK-54602, D-K052783, DK-45462]
- Westchester Artificial Kidney Foundation
Three decades ago a revolutionary idea was born that ascribed to dysfunctional endothelia some manifestations of diabetes, the Steno hypothesis, so named after the Steno Diabetes Center, Gentofte, in Denmark. Here I briefly outline the accomplishments accrued in the past 15 years to buttress this hypothesis. Those include development of novel technological platforms to examine microcirculatory beds, deeper understanding of patterns of microvascular derangement in diabetes, pathophysiology of nitric oxide synthesis and availability, nitrosative and oxidative stress in diabetes, premature senescence of endothelial cells and the role of sirtuin 1 and lyso-somal dysfunction in this process, and the state of endothelial glycocalyx and endothelial progenitor cells in diabetes. These pathophysiological findings may yield some therapeutic benefits.
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