期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 359, 期 4, 页码 609-615出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201600850
关键词
C-P functionalization; phosphorus radicals; polyheterocycles; silver; alpha,beta-unsaturated carbonyl compounds
资金
- National Natural Science Foundation of China [21573057, 21205029]
- China Postdoctoral Science Foundation [2014M552005, 2015T80770]
- Program for Innovative Research Team in University of Henan Province [17IRTSTHN001]
- National Undergraduates Innovating Experimentation Project [201510476057]
Polyheterocycle construction with high diastereoselectivity by utilizing a radical process is still problematic. In this communication, a silver-catalyzed carbon-phosphorus functionalization for polyheterocycle formation is described that furnishes good diastereoselectivity. Various substituted 1-(1H-indol-1-yl)-3-phenylprop-2-en-1-ones and phosphine oxides were suitable for this transformation. This work avoids the installation of direct functional groups and thus makes full use of shorter and more efficient synthetic processes. Preliminary mechanistic investigations indicate that phosphorus radicals are involved by attacking the -position of ,-unsaturated carbonyl compounds to generate the desired products.
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