期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 6, 期 9, 页码 1285-1291出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201700137
关键词
cross-coupling; green chemistry; ligand effects; micelles; Suzuki-Miyaura reaction
An efficient, sustainable, and broadly applicable procedure has been developed for Suzuki-Miyaura cross-coupling reactions in environmentally benign solvent (water) by employing as little as 500ppm Pd(OAc)(2) with a monophosphorus BI-DIME ligand in the presence of inexpensive and commercially available nonionic surfactant TritonX-100. This method was applied to a broad range of functionalized reaction partners, thereby affording excellent yields of the coupling products, including active pharmaceutical ingredients (APIs). An interesting kinetic study by using reaction calorimetry is also presented, which describes the effect of reaction parameters that enabled the low catalyst loading.
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