期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 45, 期 8, 页码 1665-1674出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2016.1276925
关键词
Thermosensitive polymer; poly(N-vinylcaprolactam)-g-collagen; biopolymer; controlled release; LCST
资金
- Ankara University Research Fund [14B0430002]
- Turkish Academy of Sciences (TUBA), Ankara, Turkey
In this study, we synthesized poly(N-vinylcaprolactam)-g-collagen (PNVCL-g-Col) by grafting collagen with carboxyl group-terminated thermosensitive PNVCL-COOH. The resulting biopolymer was evaluated for its structural, thermal, and rheological properties. Aqueous solutions of PNVCL-g-Col exhibited a temperature-dependent phase transition around human physiological temperature (at approximate to 38.5 degrees C), and temperature-dependent tunability. PNVCL-g-Col exhibited temperature-dependent release of the model drugs, lidocaine hydrochloride and bovine serum albumin. Thus, PNVCL-g-Col biopolymer may have wide potential use in various biomedical applications, including controlled release and tissue engineering.
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