期刊
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 77, 期 -, 页码 112-121出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejps.2015.06.004
关键词
Ciprofloxacin; Dicarboxylic acids; Pharmaceutical salts; Single crystal X-ray; Solubility; Intrinsic dissolution rate
资金
- Russian Scientific Foundation [14-13-00640]
New salts of antibiotic drug ciprofloxacin (CIP) with pharmaceutically acceptable maleic (Mlt), fumaric (Fum) and adipic (Adp) acids were obtained and their crystal structures were determined. The crystal lattices of the fumarate and adipate salts were found to accommodate the water molecules, while the maleate salt was anhydrous. The dehydration and melting processes were analyzed by means of differential scanning calorimetry and thermogravimetric analysis. Solubility and intrinsic dissolution rates of the salts were measured in pharmaceutically relevant buffer solutions with pH 1.2 and pH 6.8. Under acidic conditions, the salts were found to be less soluble than the parent form of drug, while the [CIP + Fum + H2O] and [CIP + Mlt] solids showed enhanced dissolution rate when compared to a commercially available ciprofloxacin hydrochloride hydrate. In the pH 6.8 solution, all the salts demonstrated solubility improvement and faster dissolution rate with respect to pure CIP. (C) 2015 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据