期刊
CHEMICAL COMMUNICATIONS
卷 53, 期 19, 页码 2870-2873出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc10287e
关键词
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资金
- Instituto de Salud Carlos III [Miguel Servet Program] [CP13/00211, 205024141]
- Spanish MINECO [BIO2012-32869, BIO2015-64802-R, CTQ2014- 52658-R]
- AGAUR
- ERC Council (SimDNA) [291433]
- MINECO (Government of Spain)
- European Research Council (ERC) [291433] Funding Source: European Research Council (ERC)
Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides still remains a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different sizes and complexities. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines has been reported.
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