Fast, Base-Free and Aqueous Synthesis of Quinolin-2(1H)-ones under Ambient Conditions

Without using any base and organic solvent, an environmentally benign methodology was developed for the aqueous synthesis of various functionalized quinolin-2(1H)-ones at ambient temperature. The developed protocol has a wide substrate scope, excellent to quantitative yields, short reaction time (1-8 min), operational simplicity, reusable reaction medium and avoids further chromatographic purification. More importantly, this methodology is markedly greener than the traditional routes with an E-factor of 1.6 and eco-scale score of 89.5.