期刊
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
卷 5, 期 11, 页码 10407-10412出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.7b02442
关键词
Green chemistry; Water; Quinoline N-oxide; Reissert-Henze reaction; Filtration; E-factor; Eco-scale score
资金
- National Natural Science Foundation of China [21302048]
- Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2012-318]
- Construct Program of the Key Discipline in Hunan Province
Without using any base and organic solvent, an environmentally benign methodology was developed for the aqueous synthesis of various functionalized quinolin-2(1H)-ones at ambient temperature. The developed protocol has a wide substrate scope, excellent to quantitative yields, short reaction time (1-8 min), operational simplicity, reusable reaction medium and avoids further chromatographic purification. More importantly, this methodology is markedly greener than the traditional routes with an E-factor of 1.6 and eco-scale score of 89.5.
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