期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 88, 期 -, 页码 43-51出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2017.01.033
关键词
Curcumin; Ketoconazole; Synergistic effect; Micelles; MPEG-PCL
资金
- Project of Shandong Province Higher Educational Science and Technology Program [J14LM01]
- International Cooperation Training Program of Shandong Province Higher School Outstanding Young and Middle-aged Backbone Teacher
In order to enhance water-solubility and realize controlled release while keeping synergistic effects of ketoconazole and curcumin, drug-loaded methoxy poly (ethylene glycol)-b-poly (epsilon-caprolactone) micelles were prepared through thin membrane hydration method. Transmission electric microscopy and dynamitic light scattering characterization revealed the formation of ketoconazole-and curcuminloaded micelles with an average size of 44.70 nm and 39.56 nm, respectively. The drug-loaded micelles endowed the two drugs' slow controlled release with water-solubility enhanced to 85 and 82000 folds higher than the corresponding raw drugs, respectively. In vitro antifungal activity test, chequerboard test and inhibition zone test indicated that efficacy of ketoconazole-loaded micelles was improved by introduction of curcumin-loaded micelles with a low fractional inhibitory concentration index (0.073). Biofilm formation inhibition assay also demonstrated that participation of curcumin-loaded micelles obviously strengthened the inhibition of fungal biofilms formation induced by ketoconazole-loaded micelles. The high synergistic activity of combinations is encouraging and the MPEG-PCL micelle is a potential drug delivery system for the combination of ketoconazole and curcumin. (C) 2017 Elsevier Masson SAS. All rights reserved.
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